Triethylamine → Methanesulfonic acid 2-(1-methyl-pyrrolidin-2-yl)-ethyl ester

HRID 2353486

반응식

HRID 2353486 반응식
[CH3:1][N:2]1[CH2:6][CH2:5][CH2:4][CH:3]1[CH2:7][CH2:8][OH:9].C(N(CC)CC)C.[CH3:17][S:18](Cl)(=[O:20])=[O:19]>C1COCC1>[CH3:1][N:2]1[CH2:6][CH2:5][CH2:4][CH:3]1[CH2:7][CH2:8][O:9][S:18]([CH3:17])(=[O:20])=[O:19]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 933631-Methyl-2-pyrrolidineethanol

생성물 1

HCID 44627019Methanesulfonic acid 2-(1-methyl-pyrrolidin-2-yl)-ethyl ester

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

The 1-methyl-2-pyrrolidineethanol (Aldrich, 0.16 g, 1.2 mmol), triethylamine (0.56 mL, 4.1 mmol), and methanesulfonyl chloride (0.15 mL, 1.9 mmol) in 10 mL THF were processed as described in Example 1C to give the title compound that was used directly in the next reaction.

출처 및 근거

ORD 기록
ord-635bb0d0af864afd91106917bbcf7337
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07750039B2

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