Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Morpholine → 4-(4-Nitropyridin-2-yl)morpholine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Morpholine | HCID 8083 | — |
| 반응물 | 4-Nitropyridine | HCID 70734 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-(4-Nitropyridin-2-yl)morpholine | HCID 57418546 | 56.5% |
반응 단계
To a solution of 2-chloro, 4-nitropyridine (0.2 g, 1.27 mmol) in THF (3 mL) was added morpholine (328 mg, 38.1 mmol). The reaction was heated to 80C and stirred overnight. The solvent was evaporated and the residue purified by column chromatography (2/1 Hex/EtOAc) to yield 150 mg of the target compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07749999B2 |
| 출처 데이터셋 | uspto-grants-2010_07 |
| ORD ID | ord-2980c9148a43422cb224823d9fcf9fe8 |
| 출처 메모 | uspto-grants-2010_07 |