Potassium Carbonate → 5-tert-Butyl-2-methoxy-1-methyl-3-nitro-benzene

HRID 2353552노트

반응식

HRID 2353552 반응식
[C:1]([C:5]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[C:8]([OH:14])=[C:7]([CH3:15])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[C:16]([O-])([O-])=O.[K+].[K+]>CC(C)=O>[C:1]([C:5]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[C:8]([O:14][CH3:16])=[C:7]([CH3:15])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 574185474-tert-Butyl-2-methyl-6-nitro-phenol

생성물 1

HCID 213537455-tert-Butyl-2-methoxy-1-methyl-3-nitro-benzene수율 99%

시약·촉매·용매 1

HCID 180Acetone용매

반응 조건

온도
60 °C

실험 절차

4-tert-Butyl-2-methyl-6-nitro-phenol (209 mg, 1 mmol) was dissolved in 3 mL acetone. 552 mg K2CO3 (4 eq) was added, followed by addition of Mel (0.33 mL, 5 mmol). The reaction mixture was stirred vigorously at 60° C. overnight. After removal of the acetone, the residue was shaken with DCM. Filtration and evaporation of the solution yielded 221 mg product which was used as such.

후처리

  1. additionfollowed by addition of Mel (0.33 mL, 5 mmol)
  2. customAfter removal of the acetone
  3. stirringthe residue was shaken with DCM
  4. filtrationFiltration and evaporation of the solution

출처 및 근거

ORD 기록
ord-808fd4c818db4aa5a942663546da28f9
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07749999B2

반응 노트

불러오는 중…