Phenyl isocyanate → 1-[2-Methyl-4-[4-[(3S)-3-methylmorpholin-4-yl]-6-(methylsulfonylmethyl)pyrimidin-2-yl]phenyl]-3-phenyl-urea

HRID 2353628노트

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HRID 2353628 반응식
[CH3:1][C:2]1[CH:8]=[C:7]([C:9]2[N:14]=[C:13]([N:15]3[CH2:20][CH2:19][O:18][CH2:17][C@@H:16]3[CH3:21])[CH:12]=[C:11]([CH2:22][S:23]([CH3:26])(=[O:25])=[O:24])[N:10]=2)[CH:6]=[CH:5][C:3]=1[NH2:4].[C:27]1([N:33]=[C:34]=[O:35])[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>O1CCOCC1>[CH3:1][C:2]1[CH:8]=[C:7]([C:9]2[N:14]=[C:13]([N:15]3[CH2:20][CH2:19][O:18][CH2:17][C@@H:16]3[CH3:21])[CH:12]=[C:11]([CH2:22][S:23]([CH3:26])(=[O:25])=[O:24])[N:10]=2)[CH:6]=[CH:5][C:3]=1[NH:4][C:34]([NH:33][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)=[O:35]

참가 물질

4

반응물 2

HCID 7672Phenyl isocyanateHCID 593801402-methyl-4-[4-[(3S)-3-methylmorpholin-4-yl]-6-(methylsulfonylmethyl)pyrimidin-2-yl]aniline

생성물 1

HCID 248043301-[2-Methyl-4-[4-[(3S)-3-methylmorpholin-4-yl]-6-(methylsulfonylmethyl)pyrimidin-2-yl]phenyl]-3-phenyl-urea수율 24.9%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

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온도
75 °C

실험 절차

2-Methyl-4-[4-[(3S)-3-methylmorpholin-4-yl]-6-(methylsulfonylmethyl)pyrimidin-2-yl]aniline (130 mg, 0.34 mmol) was dissolved in 1,4-dioxane (4 mL). Phenylisocyanate (0.038 mL, 0.34 mmol) was added and the reaction heated at 75° C. for 3 hours. The reaction mixture was evaporated to dryness and the resultant residue triturated with ethyl acetate to give the desired compound as a cream solid (42 mg).

후처리

  1. customThe reaction mixture was evaporated to dryness
  2. customthe resultant residue triturated with ethyl acetate

출처 및 근거

ORD 기록
ord-09931b81b9204dbca851a303bff37471
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07750003B2

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