Sodium Iodide → (S)-4-(2-Chloro-6-(iodomethyl)pyrimidin-4-YL)-3-methylmorpholine
반응식
[I-:1].[Na+].[Cl:3][C:4]1[N:9]=[C:8]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][C@@H:11]2[CH3:16])[CH:7]=[C:6]([CH2:17]OS(C)(=O)=O)[N:5]=1>C(Cl)Cl>[Cl:3][C:4]1[N:5]=[C:6]([CH2:17][I:1])[CH:7]=[C:8]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][C@@H:11]2[CH3:16])[N:9]=1참가 물질
4
반응 조건
- 온도
- 40 °C
실험 절차
Sodium iodide (1.006 ml, 24.61 mmol) was added to 2-chloro-4-[(3S)-3-methylmorpholin-4-yl]-6-(methylsulfonyloxymethyl)pyrimidine (1.584 g, 4.92 mmol) in DCM at RT. The resulting solution was refluxed at 40° C. for 18 hours. The reaction mixture was diluted with DCM and washed with water. The organic layer was dried (MgSO4), filtered and evaporated to afford the desired product (1.596 g).
후처리
- washwashed with water
- dry with materialThe organic layer was dried (MgSO4)
- filtrationfiltered
- customevaporated
출처 및 근거
- ORD 기록
- ord-0e4f3feb1fa84b7eb8d1ccc07623834a
- 출처 데이터셋
- uspto-grants-2010_07
- 특허 번호
- US07750003B2
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