5-Aminosalicylic Acid → HCID 9856513, 화합물

HRID 2353767노트

반응식

HRID 2353767 반응식
[NH2:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=[O:8])[C:5]([OH:11])=[CH:4][CH:3]=1.[F:12][C:13]1[CH:20]=[CH:19][C:16]([CH2:17]Br)=[CH:15][CH:14]=1>>[F:12][C:13]1[CH:20]=[CH:19][C:16]([CH2:17][NH:1][C:2]2[CH:10]=[C:6]([C:7]([OH:9])=[O:8])[C:5]([OH:11])=[CH:4][CH:3]=2)=[CH:15][CH:14]=1

참가 물질

3

반응물 2

HCID 40755-Aminosalicylic AcidHCID 680214-Fluorobenzyl bromide

생성물 1

HCID 9856513HCID 9856513, 화합물수율 56.4%

실험 절차

By following the similar procedure in Synthesis Example 1 by using 5-aminosalicylic acid (500 mg, 3.26 mmole) and 4-fluorobenzyl bromide (740 mg, 3.92 mmole), 480 mg (44% yield) of 5-(4-fluorobenzyl)aminosalicylic acid was obtained as a white solid.: mp>210° C. (decompose).

후처리

  1. customin Synthesis Example 1

출처 및 근거

ORD 기록
ord-377def0f845e460aba1d06615593944d
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07750045B2

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