Triethylamine → N-(4-Cyano-3-trifluoromethyl-phenyl)-2-Isopropoxy-benzamide

HRID 2353805노트

반응식

HRID 2353805 반응식
[CH:1]([O:4][C:5]1[CH:13]=[CH:12][CH:11]=[CH:10][C:6]=1[C:7](Cl)=[O:8])([CH3:3])[CH3:2].[NH2:14][C:15]1[CH:22]=[CH:21][C:18]([C:19]#[N:20])=[C:17]([C:23]([F:26])([F:25])[F:24])[CH:16]=1.C(N(CC)CC)C>ClCCl>[C:19]([C:18]1[CH:21]=[CH:22][C:15]([NH:14][C:7](=[O:8])[C:6]2[CH:10]=[CH:11][CH:12]=[CH:13][C:5]=2[O:4][CH:1]([CH3:3])[CH3:2])=[CH:16][C:17]=1[C:23]([F:24])([F:25])[F:26])#[N:20]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 5221704-Amino-2-(trifluoromethyl)benzonitrileHCID 159219142-(Propan-2-yloxy)benzoyl chloride

생성물 1

HCID 68453992N-(4-Cyano-3-trifluoromethyl-phenyl)-2-Isopropoxy-benzamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

2-Isopropoxy-benzoyl chloride was condensed with 4-Amino-2-trifluoromethyl benzonitrile in dichloromethane in presence of triethylamine as acid scavenger to yield N-(4-Cyano-3-trifluoromethyl-phenyl)-2-Isopropoxy-benzamide. The reaction mixture was then concentrated in vacuo and the residue was extracted into ethyl acetate. The ethyl acetate layer was washed with water and with cold aqueous hydrochloric acid, then dried over sodium sulphate and finally concentrated in vacuo. The residue obtained was chromatographed over silica gel to afford the desired product.

출처 및 근거

ORD 기록
ord-1cf27539947a47ddba2d147a1a9556a8
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07750047B2

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