Piperidine → p-Piperidinophenol

HRID 2354032노트

반응식

HRID 2354032 반응식
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:7]1(=O)[CH2:12][CH2:11][C:10](=[O:13])[CH2:9][CH2:8]1>C(O)C>[OH:13][C:10]1[CH:11]=[CH:12][C:7]([N:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)=[CH:8][CH:9]=1

참가 물질

4

반응물 2

HCID 8082PiperidineHCID 125111,4-Cyclohexanedione

생성물 1

HCID 90452p-Piperidinophenol수율 53.7%

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

0.85 g of piperidine and 2.24 g of 1,4-cyclohexanedione were heated with stirring in 15 ml of ethanol at 50 to 60° C. and reacted in air for 8 hours. During the reaction, ethanol was added as needed. After the completion of the reaction, the reaction mixture was concentrated under reduced pressure and the resultant was separated by silica gel column chromatography (n-hexane:ethyl acetate=2:1) and 0.95 g of 1-(4-hydroxyphenyl)piperidine was obtained (yield 53.7%).

후처리

  1. customreacted in air for 8 hours
  2. additionwas added
  3. customAfter the completion of the reaction
  4. concentrationthe reaction mixture was concentrated under reduced pressure
  5. customthe resultant was separated by silica gel column chromatography (n-hexane:ethyl acetate=2:1)

출처 및 근거

ORD 기록
ord-ebb719dd853f4f03b43312b907521a64
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07750156B2

반응 노트

불러오는 중…