2-(4-Benzylpiperidin-1-yl)ethan-1-amine → 1-[2-(4-Benzyl-piperidin-1-yl)-ethyl]-3-(2,6-dimethyl-pyridin-4-yl)-urea

HRID 2354073노트

반응식

HRID 2354073 반응식
[CH2:1]([CH:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][NH2:16])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:17][C:18]1[CH:23]=[C:22]([NH:24][C:25](NC2C=C(C)N=C(C)C=2)=[O:26])[CH:21]=[C:20]([CH3:36])[N:19]=1>O1CCOCC1>[CH2:1]([CH:8]1[CH2:9][CH2:10][N:11]([CH2:14][CH2:15][NH:16][C:25]([NH:24][C:22]2[CH:23]=[C:18]([CH3:17])[N:19]=[C:20]([CH3:36])[CH:21]=2)=[O:26])[CH2:12][CH2:13]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 27798312-(4-Benzylpiperidin-1-yl)ethan-1-amineHCID 593811911,3-Bis-(2,6-dimethyl-pyridin-4-yl)-urea

생성물 1

HCID 112686091-[2-(4-Benzyl-piperidin-1-yl)-ethyl]-3-(2,6-dimethyl-pyridin-4-yl)-urea

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A suspension of 2-(4-benzylpiperidino)-1-ethanamine (Example B1, 54.6 mg, 0.25 mmol), TEA (35 μL, 0.25 mmol) and 1,3-bis-(2,6-dimethyl-pyridin-4-yl)-urea (Example B1, 67.6 mg 0.25 mmol) in dioxane (2 mL) is heated at reflux for 24 h. The solvent is evaporated and the residue purified by HPLC to provide the title compound.

후처리

  1. temperatureis heated
  2. temperatureat reflux for 24 h
  3. customThe solvent is evaporated
  4. customthe residue purified by HPLC

출처 및 근거

ORD 기록
ord-e85a7bea8fe44e78ad591894a1e7ec73
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07750161B2

반응 노트

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