HCID 86614812, 화합물 → HCID 86614818, 화합물

HRID 2354122노트

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HRID 2354122 반응식
[CH3:1][C:2]1[C:10]([CH3:19])([CH2:11][CH2:12][CH2:13][CH2:14][S:15]([O-:18])(=[O:17])=[O:16])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([S:20]([O-:23])(=[O:22])=[O:21])[CH:8]=2)[N:3]=1.[Na+:24].[Na+]>C1COS(=O)(=O)CC1>[CH3:1][C:2]1[C:10]([CH3:19])([CH2:11][CH2:12][CH2:13][CH2:14][S:15]([O-:18])(=[O:16])=[O:17])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([S:20]([O-:23])(=[O:21])=[O:22])[CH:8]=2)[N+:3]=1[CH2:11][CH2:12][CH2:13][CH2:14][S:15]([O-:18])(=[O:17])=[O:16].[Na+:24].[Na+:24]

참가 물질

3

반응물 1

HCID 86614812HCID 86614812, 화합물

생성물 1

HCID 86614818HCID 86614818, 화합물수율 217.1%

시약·촉매·용매 1

HCID 154111,4-Butane sultone용매

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온도
150 °C

실험 절차

Disodium 2,3-dimethyl-3-(4-sulphonatobutyl)-3H-indole-5-sulphonate (1.0 g) and 1,4-butanesultone (10 ml) were mixed and heated under nitrogen at 150° C. for 52 hrs to give a dark purple slurry. After cooling, the mixture was triturated with ethyl acetate: the solid portion was collected by filtration, washed with ethyl acetate and diethyl ether, then dried under high vacuum over phosphorus pentoxide to give the title product (1.45 g), which was used directly without purification.

후처리

  1. customto give a dark purple slurry
  2. temperatureAfter cooling
  3. customthe mixture was triturated with ethyl acetate
  4. filtrationthe solid portion was collected by filtration
  5. washwashed with ethyl acetate and diethyl ether
  6. dry with materialdried under high vacuum over phosphorus pentoxide

출처 및 근거

ORD 기록
ord-60c1b375520d467ca00298cdec5db044
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07750163B2

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