2-Methylpiperazine, (R)- → HCID 69572452, 화합물
반응식
[CH3:1][C@@H:2]1[CH2:7][NH:6][CH2:5][CH2:4][NH:3]1.Cl[C:9]1[CH:10]=[CH:11][C:12]([N+:31]([O-:33])=[O:32])=[C:13]([CH:30]=1)[C:14]([NH:16][C:17]1[CH:22]=[C:21]([C:23]([NH:25][CH:26]2[CH2:28][CH2:27]2)=[O:24])[CH:20]=[CH:19][C:18]=1[CH3:29])=[O:15]>>[CH:26]1([NH:25][C:23]([C:21]2[CH:20]=[CH:19][C:18]([CH3:29])=[C:17]([NH:16][C:14](=[O:15])[C:13]3[CH:30]=[C:9]([N:6]4[CH2:5][CH2:4][NH:3][C@H:2]([CH3:1])[CH2:7]4)[CH:10]=[CH:11][C:12]=3[N+:31]([O-:33])=[O:32])[CH:22]=2)=[O:24])[CH2:28][CH2:27]1참가 물질
3
실험 절차
Using an analogous procedure to that described paragraph (B) in the portion of Example 1 which is concerned with the preparation of starting material (R)-2-methylpiperazine was reacted with 5-chloro-N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-2-nitrobenzamide to give N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-5-[(3R)-3-methylpiperazine-1-yl)-2-nitrobenzamide; NMR Spectrum: (DMSOd6) 0.56 (m, 2H), 0.67 (m, 2H), 1.04 (d, 3H), 2.30 (s, 3H), 2.52 (m, 2H), 2.71 (m, 2H), 2.84 (m, 2H), 2.98 (d, 1H), 3.92 (t, 2H), 7.04 (m, 2H), 7.27 (d, 1H), 7.56 (d, 1H), 7.97 (s, 1H), 8.03 (d, 2H), 8.35 (d, 1H), 9.88 (s, 1H); Mass Spectrum: M+H+ 438.
출처 및 근거
- ORD 기록
- ord-2927c8cd883b47cfaa2cb3ae0f86cc20
- 출처 데이터셋
- uspto-grants-2010_07