Triethylamine → HCID 46941029, 화합물

BOP (133 mg, 0.30 mmol) was added to a mixture containing (5-chloro-2-oxo-1,3-benzoxazol-3(2H)-yl)acetic acid (68 mg, 0.30 mmol), 2-(4-biphenylyl)-N-methyl-1-(1-pyrrolidinyl)-2-propanamine (74 mg, 0.25 mmol) and Et3N (0.042 ml, 0.30 mmol) in DMF (3 ml) and the resulting mixture was stirred at room temperature for 16 h. The crude reaction mixture was purified by preparative HPLC (Xterra PrepRP 30×100 mm, 45 mL/min, A: acetonitrile B: water, PH 10, A: 50 to 90% over 12 min, UV detection at 214 nm) to give 17.5 mg (13.9%) as a white solid. MS (ES) m/e 504.4 [M+H]+.

1. customThe crude reaction mixture
2. customwas purified by preparative HPLC (Xterra PrepRP 30×100 mm, 45 mL/min
3. waitA: acetonitrile B: water, PH 10, A: 50 to 90% over 12 min
4. customUV detection at 214 nm) to give 17.5 mg (13.9%) as a white solid

ORD 기록

ord-3afe8813d29046a0899afd960a895139

출처 데이터셋

uspto-grants-2010_07

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US07749998B2