p-Toluenesulfonic acid → 2-(4-Bromophenyl)benzothiazole
반응식
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[SH:8].[Br:9][C:10]1[CH:17]=[CH:16][C:13]([CH:14]=O)=[CH:12][CH:11]=1.CC1C=CC(S(O)(=O)=O)=CC=1>C1(C)C=CC=CC=1>[Br:9][C:10]1[CH:17]=[CH:16][C:13]([C:14]2[S:8][C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[N:1]=2)=[CH:12][CH:11]=1참가 물질
5
실험 절차
2-aminothiophenol 9.01 g (72 mmole), 4-bromobenzaldehyde 16 g (87 mmole), and 2.8 g of PTSA (14 mmole) was stirred in 150 ml of Toluene, the reaction mixture was then heated to reflux for 16 hours, after cooling, the reaction mixture was extracted with water, and then the organic layer was evaporated to dry, the residue was then recrystallized with acetone to get 13.43 g of product (yield=64.3%).
후처리
- temperaturethe reaction mixture was then heated
- temperatureto reflux for 16 hours
- temperatureafter cooling
- extractionthe reaction mixture was extracted with water
- customthe organic layer was evaporated
- customto dry
- customthe residue was then recrystallized with acetone
출처 및 근거
- ORD 기록
- ord-7b6fb0299e9b4caf970788efb9b36d15
- 출처 데이터셋
- uspto-grants-2010_07
- 특허 번호
- US07754348B2
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