(+)-3-Benzo[1,3]dioxol-5-ylmethyl-1-benzyl-piperidine → 3-Benzo[1,3]dioxol-5-ylmethyl-piperidine

HRID 2354564노트

반응식

HRID 2354564 반응식
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][CH:11]3[CH2:16][CH2:15][CH2:14][N:13](CC4C=CC=CC=4)[CH2:12]3)=[CH:9][C:4]=2[O:3][CH2:2]1>CO>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][CH:11]3[CH2:16][CH2:15][CH2:14][NH:13][CH2:12]3)=[CH:9][C:4]=2[O:3][CH2:2]1

참가 물질

3

반응물 1

HCID 68451530(+)-3-Benzo[1,3]dioxol-5-ylmethyl-1-benzyl-piperidine

생성물 1

HCID 170395273-Benzo[1,3]dioxol-5-ylmethyl-piperidine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

1.40 g (4.5 mmol) of (+)-3-benzo[1,3]dioxol-5-ylmethyl-1-benzyl-piperidine is dissolved in 35 ml MeOH and 1 ml AcOH and hydrogenated over Pd/C 10% (0.3 g) for 2 d until hydrogen absorption is complete. The mixture is filtered over Celite®, and the filtrate is evaporated, diluted with CH2Cl2, washed with sat. aq. Na2CO3 solution and evaporated to give (+)-3-benzo[1,3]dioxol-5-ylmethyl-piperidine ([α]Drt=5.90 (c=0.5, DMSO)) which is used without further purification.

후처리

  1. custom1 ml AcOH and hydrogenated over Pd/C 10% (0.3 g) for 2 d until hydrogen absorption
  2. filtrationThe mixture is filtered over Celite®
  3. customthe filtrate is evaporated
  4. additiondiluted with CH2Cl2
  5. washwashed with sat. aq. Na2CO3 solution
  6. customevaporated

출처 및 근거

ORD 기록
ord-e6282ada6480498a9f7db1b50b815a7a
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07754719B2

반응 노트

불러오는 중…