6-Amino-3-chloropyridazine → 6-[4-(2-TRIFLUOROMETHYLBENZOYL)PIPERAZIN-1-YL]PYRIDAZINE-3-CARBOXYLIC Acid (6-CHLOROPYRIDAZIN-3-YL)AMIDE
반응식
[NH2:1][C:2]1[N:3]=[N:4][C:5]([Cl:8])=[CH:6][CH:7]=1.[F:9][C:10]([F:35])([F:34])[C:11]1[CH:33]=[CH:32][CH:31]=[CH:30][C:12]=1[C:13]([N:15]1[CH2:20][CH2:19][N:18]([C:21]2[N:26]=[N:25][C:24]([C:27](O)=[O:28])=[CH:23][CH:22]=2)[CH2:17][CH2:16]1)=[O:14]>>[Cl:8][C:5]1[N:4]=[N:3][C:2]([NH:1][C:27]([C:24]2[N:25]=[N:26][C:21]([N:18]3[CH2:17][CH2:16][N:15]([C:13](=[O:14])[C:12]4[CH:30]=[CH:31][CH:32]=[CH:33][C:11]=4[C:10]([F:35])([F:34])[F:9])[CH2:20][CH2:19]3)=[CH:22][CH:23]=2)=[O:28])=[CH:7][CH:6]=1참가 물질
3
실험 절차
Following the procedure of Example 24, making variations only as required to use 3-amino-6-chloropyridazine in place of 2,2-(dimethylcyclopropyl)methylamine to react with 6-[4-(2-trifluoromethylbenzoyl)piperazin-1-yl]pyridazine-3-carboxylic acid, the title compound was obtained as a white powder (8% yield). 1H NMR (300 MHz, CDCl3) δ 10.75, 8.62, 8.06, 7.75-7.50, 7.36, 7.03, 4.12-3.76, 3.36. 13C NMR (75 MHz, CDCl3) δ 167.7, 162.2, 160.1, 154.0, 152.3 143.8, 134.1, 132.4, 129.7, 129.6, 127.3, 127.2, 126.94, 126.88, 126.7, 120.7, 112.2, 46.3, 44.6, 44.3, 41.3. MS (ES+) m/z 492.1 (M+1).
출처 및 근거
- ORD 기록
- ord-91a26d1735074ba083c9518cea0ee1dc
- 출처 데이터셋
- uspto-grants-2010_07
- 특허 번호
- US07754711B2
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