반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([NH2:7])[N:2]=1.[F:8][C:9]([F:34])([F:33])[C:10]1[CH:32]=[CH:31][CH:30]=[CH:29][C:11]=1[C:12]([N:14]1[CH2:19][CH2:18][N:17]([C:20]2[N:25]=[N:24][C:23]([C:26](Cl)=[O:27])=[CH:22][CH:21]=2)[CH2:16][CH2:15]1)=[O:13]>>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([NH:7][C:26]([C:23]2[N:24]=[N:25][C:20]([N:17]3[CH2:16][CH2:15][N:14]([C:12](=[O:13])[C:11]4[CH:29]=[CH:30][CH:31]=[CH:32][C:10]=4[C:9]([F:34])([F:33])[F:8])[CH2:19][CH2:18]3)=[CH:21][CH:22]=2)=[O:27])[N:2]=1참가 물질
3
실험 절차
Following the procedure of Example 28, making variations only as required to use pyridazin-3-ylamine in place of 2-aminopyridine to react with 6-[4-(2-trifluoromethylbenzoyl)-piperazin-1-yl]pyridazine-3-carbonyl chloride, the title compound was obtained as a white powder (17.3% yield). 1H NMR (300 MHz, CDCl3) δ 10.81, 9.05, 8.70, 8.13, 7.87-7.57, 7.39, 6.95, 4.16-3.80, 3.40. 13C NMR (300 MHz, CDCl3) δ 167.7, 162.3, 160.1, 148.6, 144.1, 132.4, 129.6, 128.1, 127.2, 126.9, 118.3, 112.1, 43.4, 44.6, 44.3, 41.3. MS (ES+) m/z 458.3 (M+1).
출처 및 근거
- ORD 기록
- ord-4b583b06c09a484bb1b83d977612587f
- 출처 데이터셋
- uspto-grants-2010_07
- 특허 번호
- US07754711B2
연결된 노트
불러오는 중…