Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Chloroform → 5-bromo-2-(N-ethyl-2,4-dichloroanilino)-4-methylthiazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Chloroform | HCID 6212 | — |
| 반응물 | Calcium Carbonate | HCID 10112 | — |
| 반응물 | 2-(N-ethyl-2,4-dichloroanilino)-4-methylthiazole hydrochloride | HCID 22574426 | — |
| 반응물 | Benzyltrimethylammoniumtribromide | HCID 53442637 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 5-bromo-2-(N-ethyl-2,4-dichloroanilino)-4-methylthiazole | HCID 12134665 | 117.9% |
반응 단계
After 2-(N-ethyl-2,4-dichloroanilino)-4-methylthiazole hydrochloride (6.0 g) and calcium carbonate (4.6 g) were suspended in a mixed solvent of chloroform (90 mL) and methanol (36 mL), benzyl-trimethylammonium tribromide (7.2 g) was added thereto in small portions. The solids in the reaction mixture were filtered off and the filtrate was concentrated under reduced pressure. The residue was purified by a silica gel column chromatography (silica gel: Wako Gel (C200), eluent: hexane-ethyl acetate=9:1) to obtain 5-bromo-2-(N-ethyl-2,4-dichloroanilino)-4-methyl-thiazole (4.5 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06852732B2 |
| 출처 데이터셋 | uspto-grants-2005_02 |
| ORD ID | ord-34198016cd934b30945836604352d606 |
| 출처 메모 | uspto-grants-2005_02 |