HCID 86612423, 화합물 → HCID 86612424, 화합물

HRID 2355242노트

반응식

HRID 2355242 반응식
C(OC([NH:8][C:9]([CH3:24])([CH3:23])[CH2:10][CH2:11][N:12]1[C:20]2[C:15](=[CH:16][C:17]([CH:21]=[O:22])=[CH:18][CH:19]=2)[CH:14]=[CH:13]1)=O)(C)(C)C>O>[NH2:8][C:9]([CH3:24])([CH3:23])[CH2:10][CH2:11][N:12]1[C:20]2[C:15](=[CH:16][C:17]([CH:21]=[O:22])=[CH:18][CH:19]=2)[CH:14]=[CH:13]1

참가 물질

3

반응물 1

HCID 86612423HCID 86612423, 화합물

생성물 1

HCID 86612424HCID 86612424, 화합물

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
150 °C

실험 절차

A suspension of 1-(3-tert-butoxycarbonylamino-3-methyl-butyl)-1H-indole-5-carbaldehyde (3.5 g; 10.6 mmol) in 18 ml of water is heated for 19 hours at 150° C. in the microwave. Then the reaction mixture is extracted with DCM, dried on magnesium sulphate and freed from the solvent in vacuo. The residue is chromatographed on silica gel (DCM/methanol=1:1).

후처리

  1. extractionThen the reaction mixture is extracted with DCM
  2. customdried on magnesium sulphate
  3. customThe residue is chromatographed on silica gel (DCM/methanol=1:1)

출처 및 근거

ORD 기록
ord-117d31abe95149f6aa01f036f0ac39bf
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07754756B2

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