Water → Methyl [(1H-indol-5-yl)oxy]acetate

HRID 2355257노트

반응식

HRID 2355257 반응식
[OH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[CH:5]2.C(=O)([O-])[O-].[Cs+].[Cs+].Br[CH2:18][C:19]([O:21][CH2:22]C)=[O:20].O>CC(C)=O.C(Cl)Cl>[NH:7]1[C:8]2[C:4](=[CH:3][C:2]([O:1][CH2:18][C:19]([O:21][CH3:22])=[O:20])=[CH:10][CH:9]=2)[CH:5]=[CH:6]1

참가 물질

7

반응물 4

HCID 962WaterHCID 7748Ethyl bromoacetateHCID 10796Cesium carbonateHCID 160545-Hydroxyindole

생성물 1

HCID 59808925Methyl [(1H-indol-5-yl)oxy]acetate

시약·촉매·용매 2

HCID 180Acetone용매HCID 6344Dichloromethane용매

실험 절차

A suspension of 5-hydroxyindole (5.00 g; 37.6 mmol), caesium carbonate (26.9 g, 82.6 mmol) and ethyl bromoacetate (4.60 g, 30.0 mmol) in 100 ml acetone is stirred for 18 hours at ambient temperature. Then the reaction mixture is combined with water and DCM. The phases are separated and the aqueous phase is extracted with DCM. The combined phases are dried on sodium sulphate and freed from the solvent in vacuo.

후처리

  1. customThe phases are separated
  2. extractionthe aqueous phase is extracted with DCM
  3. customThe combined phases are dried on sodium sulphate

출처 및 근거

ORD 기록
ord-fcd5193f926f4eea8bbee093f190ba5e
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07754756B2

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