Water → 1-Benzyloxycarbonylmethyl-2,4-dioxopyrimidine

HRID 23555

반응식

HRID 23555 반응식
[O:1]=[C:2]1[NH:7][C:6](=[O:8])[CH:5]=[CH:4][NH:3]1.Br[CH2:10][C:11]([O:13][CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:12].C(=O)([O-])[O-].[K+].[K+].O>CN(C=O)C>[O:1]=[C:2]1[NH:7][C:6](=[O:8])[CH:5]=[CH:4][N:3]1[CH2:10][C:11]([O:13][CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:12]

참가 물질

6

반응물 4

HCID 962WaterHCID 1174UracilHCID 11430Potassium CarbonateHCID 62576Benzyl bromoacetate

생성물 1

HCID 226011191-Benzyloxycarbonylmethyl-2,4-dioxopyrimidine수율 60.3%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of 2,4-dioxopyrimidine (1.0 g) in anhydrous DMF (10 ml) were added benzyl bromoacetate (2.5 g) and potassium carbonate (2.5 g). After stirring at room temperature for 15 hours, the reaction mixture was poured into water and extracted with ethyl acetate. The organic phase was washed with brine and then dried with magnesium sulfate, filtered and evaporated under reduced pressure. The precipitate was washed with diethyl ether to give phenylmethyl 2-(2,4-dioxo-1,3-dihydropyrimidinyl)acetate (1.4 g) as a colorless solid.

후처리

  1. extractionextracted with ethyl acetate
  2. washThe organic phase was washed with brine
  3. dry with materialdried with magnesium sulfate
  4. filtrationfiltered
  5. customevaporated under reduced pressure
  6. washThe precipitate was washed with diethyl ether

출처 및 근거

ORD 기록
ord-0c6dbf2897d04754b15dfbc2d2793da6
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06852744B2

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