Potassium Carbonate → 2-[4-(6-chlorobenzoxazol-2-yloxy)phenoxy]propionic acid N-cyano-N-butylamide

HRID 235550노트

반응식

HRID 235550 반응식
[C:1]([N:3]([CH2:16][CH2:17][CH2:18][CH3:19])[C:4](=[O:15])[CH:5]([O:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1O)[CH3:6])#[N:2].Cl[C:21]1[O:22][C:23]2[CH:29]=[C:28]([Cl:30])[CH:27]=[CH:26][C:24]=2[N:25]=1.C(=O)([O-])[O-:32].[K+].[K+]>C(#N)C>[C:1]([N:3]([CH2:16][CH2:17][CH2:18][CH3:19])[C:4](=[O:15])[CH:5]([O:7][C:8]1[CH:13]=[CH:12][C:11]([O:32][C:21]2[O:22][C:23]3[CH:29]=[C:28]([Cl:30])[CH:27]=[CH:26][C:24]=3[N:25]=2)=[CH:10][CH:9]=1)[CH3:6])#[N:2]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 771752,6-DichlorobenzoxazoleHCID 538549152-(hydroxyphenoxy)propionic acid N-cyano-N-butylamide

생성물 1

HCID 544438442-[4-(6-chlorobenzoxazol-2-yloxy)phenoxy]propionic acid N-cyano-N-butylamide

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

4.4 g (0.017 mole) of 2-(hydroxyphenoxy)propionic acid N-cyano-N-butylamide, 3.8 g (0.02 mole) of 2,6-dichlorobenzoxazole and 3.5 g (0.025 mole) of potassium carbonate are stirred in 50 ml of acetonitrile for 10 hours at room temperature. The salts are then removed by filtration and the filtrate is concentrated by evaporation. The residue is chromatographed through silica gel eluted with ethyl acetate/hexane (1:3), affording 2-[4-(6-chlorobenzoxazol-2-yloxy)phenoxy]propionic acid N-cyano-N-butylamide with a melting point of 91°-92° C.

후처리

  1. customThe salts are then removed by filtration
  2. concentrationthe filtrate is concentrated by evaporation
  3. customThe residue is chromatographed through silica gel
  4. washeluted with ethyl acetate/hexane (1:3)

출처 및 근거

ORD 기록
ord-bf91bdf48a3545d9a0a0c76b2731c5c0
출처 데이터셋
uspto-grants-1987_02
특허 번호
US04640703

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