(3S,4S)-benzyl 3-((R)-3-((S)-1-(3-chloro-2-fluorophenyl)-1-hydroxy-5-methoxypentyl)piperidine-1-carboxamido)-4-cyclohexylpiperidine-1-carboxylate → (3R)-3-((S)-1-(3-chloro-2-fluorophenyl)-1-hydroxy-5-methoxypentyl)-N-((3RS,4RS)-4-cyclohexylpiperidin-3-yl)piperidine-1-carboxamide
반응식
[Cl:1][C:2]1[C:3]([F:47])=[C:4]([C@:8]([C@@H:16]2[CH2:21][CH2:20][CH2:19][N:18]([C:22]([NH:24][C@H:25]3[C@H:30]([CH:31]4[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]4)[CH2:29][CH2:28][N:27](C(OCC4C=CC=CC=4)=O)[CH2:26]3)=[O:23])[CH2:17]2)([OH:15])[CH2:9][CH2:10][CH2:11][CH2:12][O:13][CH3:14])[CH:5]=[CH:6][CH:7]=1>[Pd](Cl)Cl.CCOC(C)=O>[Cl:1][C:2]1[C:3]([F:47])=[C:4]([C@:8]([C@@H:16]2[CH2:21][CH2:20][CH2:19][N:18]([C:22]([NH:24][CH:25]3[CH:30]([CH:31]4[CH2:32][CH2:33][CH2:34][CH2:35][CH2:36]4)[CH2:29][CH2:28][NH:27][CH2:26]3)=[O:23])[CH2:17]2)([OH:15])[CH2:9][CH2:10][CH2:11][CH2:12][O:13][CH3:14])[CH:5]=[CH:6][CH:7]=1참가 물질
4
