1,1'-Carbonyldiimidazole → 1-Benzylimidazolidin-2-one

HRID 23558

반응식

HRID 23558 반응식
[CH2:1]([NH:8][CH2:9][CH2:10][NH2:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:12](N1C=CN=C1)(N1C=CN=C1)=[O:13]>C1(C)C=CC=CC=1>[CH2:1]([N:8]1[CH2:9][CH2:10][NH:11][C:12]1=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 682631,1'-CarbonyldiimidazoleHCID 77801N-Benzylethylenediamine

생성물 1

HCID 2314031-Benzylimidazolidin-2-one수율 49.2%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To a solution of N-benzylethylenediamine (6.0 g, 40 mmol) in toluene (50 ml) at 0° C. was added 1,1′-carbonylbis-1H-imidazole (7.8 g, 48 mmol). After stirring the mixture at room temperature overnight, the reaction mixture was washed with water, 5% aqueous citric acid solution and brine. The organic phase was dried over anhydrous magnesium sulfate, filtered and evaporated under reduced pressure. The residue was recrystallized with warm ethyl acetate and filtered off to give 1-benzylimidazolidin-2-one (3.47 g).

후처리

  1. washthe reaction mixture was washed with water, 5% aqueous citric acid solution and brine
  2. dry with materialThe organic phase was dried over anhydrous magnesium sulfate
  3. filtrationfiltered
  4. customevaporated under reduced pressure
  5. customThe residue was recrystallized with warm ethyl acetate
  6. filtrationfiltered off

출처 및 근거

ORD 기록
ord-25f7d1db2d0b40efa6b910d5b1689781
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06852744B2

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