1,1'-Carbonyldiimidazole → 1-Benzylimidazolidin-2-one
반응식
[CH2:1]([NH:8][CH2:9][CH2:10][NH2:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:12](N1C=CN=C1)(N1C=CN=C1)=[O:13]>C1(C)C=CC=CC=1>[CH2:1]([N:8]1[CH2:9][CH2:10][NH:11][C:12]1=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1참가 물질
4
실험 절차
To a solution of N-benzylethylenediamine (6.0 g, 40 mmol) in toluene (50 ml) at 0° C. was added 1,1′-carbonylbis-1H-imidazole (7.8 g, 48 mmol). After stirring the mixture at room temperature overnight, the reaction mixture was washed with water, 5% aqueous citric acid solution and brine. The organic phase was dried over anhydrous magnesium sulfate, filtered and evaporated under reduced pressure. The residue was recrystallized with warm ethyl acetate and filtered off to give 1-benzylimidazolidin-2-one (3.47 g).
후처리
- washthe reaction mixture was washed with water, 5% aqueous citric acid solution and brine
- dry with materialThe organic phase was dried over anhydrous magnesium sulfate
- filtrationfiltered
- customevaporated under reduced pressure
- customThe residue was recrystallized with warm ethyl acetate
- filtrationfiltered off
출처 및 근거
- ORD 기록
- ord-25f7d1db2d0b40efa6b910d5b1689781
- 출처 데이터셋
- uspto-grants-2005_02
- 특허 번호
- US06852744B2
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