1,3-Propanediol → 4-(1,3,2-Dioxaborinan-2-yl)benzoic acid

HRID 2356076노트

반응식

HRID 2356076 반응식
[OH:1][B:2]([OH:12])[C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][CH:4]=1.[CH2:13](O)[CH2:14][CH2:15]O>C1(C)C=CC=CC=1>[O:1]1[CH2:15][CH2:14][CH2:13][O:12][B:2]1[C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][CH:4]=1

참가 물질

4

반응물 2

HCID 104421,3-PropanediolHCID 3121834-Carboxyphenylboronic Acid

생성물 1

HCID 145278654-(1,3,2-Dioxaborinan-2-yl)benzoic acid

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A mixture of 4-(dihydroxyboryl)benzoic acid (30.00 g, 181 mmol) and 1,3-propanediol (15.20 g, 200 mmol) in toluene (750 mL) at 140° C. was stirred for 6 hours while collecting the water removed by azeotrope formation. The mixture was concentrated to provide the desired product.

후처리

  1. customwhile collecting the water
  2. customremoved by azeotrope formation
  3. concentrationThe mixture was concentrated

출처 및 근거

ORD 기록
ord-8a80a9a9a3624b2cac0e71a14c74c267
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07754886B2

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