HCID 22730718, 화합물 → 1,1-Dimethylethyl N-[4-hydroxy-1-[(phenylthio)methyl]butyl]carbamate

HRID 2356116노트

반응식

HRID 2356116 반응식
[C:1]([O:5][C:6]([NH:8][CH:9]([CH2:16][S:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH2:10][CH2:11][C:12](OC)=[O:13])=[O:7])([CH3:4])([CH3:3])[CH3:2].C([BH-](CC)CC)C.[Li+]>C1COCC1>[OH:13][CH2:12][CH2:11][CH2:10][CH:9]([NH:8][C:6](=[O:7])[O:5][C:1]([CH3:3])([CH3:2])[CH3:4])[CH2:16][S:17][C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

참가 물질

4

반응물 2

HCID 22730718HCID 22730718, 화합물HCID 23664628Lithiumtriethylborohydride

생성물 1

HCID 227307071,1-Dimethylethyl N-[4-hydroxy-1-[(phenylthio)methyl]butyl]carbamate

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

A solution of Example 384B (538 mg, 1.6 mmol) in THF (4 mL) at −50° C. was treated with 1M lithium triethylborohydride in THF (4 mL), stirred for 1 hour, poured into ice (˜15 g), and extracted with ethyl acetate (100 mL). The extract was washed with water (20 mL) and brine (10 mL), dried (MgSO4), filtered, and concentrated to provide the desired product of sufficient purity for subsequent use.

후처리

  1. extractionextracted with ethyl acetate (100 mL)
  2. washThe extract was washed with water (20 mL) and brine (10 mL)
  3. dry with materialdried (MgSO4)
  4. filtrationfiltered
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-8378bf771a6f4d2998c1b76f01d480e3
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07754886B2

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