Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetyl chloride → cis-8-Benzyl-2-acetyl-2,8-diazabicyclo[4,3,0]nonane
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetyl chloride | HCID 6367 | — |
| 반응물 | (4aS-cis-)-6-benzyl-octahydropyrrolo(3.4-b)pyridine | HCID 10198297 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | cis-8-Benzyl-2-acetyl-2,8-diazabicyclo[4,3,0]nonane | HCID 67237118 | 85.5% |
반응 단계
The preparation comprises dissolving cis-8-benzyl-2,8-diazabicyclo[4,3,0]nonane (5.0 g, 23.1 mmol) in dichloromethane (50 mL) and triethylamine (5 mL) under stirring in ice bath, dropwise adding a solution of acetyl chloride (1.8 g, 23.1 mmol) in chloroform (10 mL), continuing with the stirring until the reaction finishes, distilling off the solvent, and chromatographing on silica gel with petroleum ether and ethyl acetate to give cis-8-benzyl-2-acetyl-2,8-diazabicyclo[4,3,0]nonane (5.1 g, 85.5%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07759362B2 |
| 출처 데이터셋 | uspto-grants-2010_07 |
| ORD ID | ord-73dba824b6a34dd4a3e3a31b28376924 |
| 출처 메모 | uspto-grants-2010_07 |