Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2356391생성일: 2026년 10월 27일
Potassium Carbonate → 4-(2-Ethyl-6-fluoro-3-{1-[3-(4-fluoro-phenylsulfanyl)-propyl]-piperidin-4-YL}-indol-1-YL)-benzoic acid ethyl ester
https://huagongshe.com/reaction/2356391
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 반응물 | Ethyl 4-iodobenzoate | HCID 142891 | — |
| 반응물 | 2-Ethyl-6-fluoro-3-{1-[3-(4-fluoro-phenylsulfanyl)-propyl]-piperidin-4-yl}-1H-indole | HCID 57718837 | — |
| 촉매 | Copper iodide | HCID 83717 | — |
| 촉매 | Zinc Oxide | HCID 3007857 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 4-(2-Ethyl-6-fluoro-3-{1-[3-(4-fluoro-phenylsulfanyl)-propyl]-piperidin-4-YL}-indol-1-YL)-benzoic acid ethyl ester | HCID 11952525 | 26% |
반응 단계
To a mixture of 2-ethyl-6-fluoro-3-{1-[3-(4-fluoro-phenylsulfanyl)-propyl]-piperidin-4-yl}-1H-indole (430 mg), p-iodobenzoic acid ethyl ester (716 mg), potassium carbonate (359 mg), copper iodide (52 mg) and zinc oxide (14 mg) in a reactor vial under argon is added NMP (3 ml) and the reaction heated by microwaves irradiation at 160° C. After 120 min, water is added and the suspension extracted with DCM. Preparative HPLC provides 150 mg pure product (26%) as a beige solid. R.t. 4.81 min.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07759365B2 |
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| 출처 데이터셋 | uspto-grants-2010_07 |
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| ORD ID | ord-539983f68fff4a7cb10bbbe8046a7874 |
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| 출처 메모 | uspto-grants-2010_07 |
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