Water → 4-tert-Butoxycarbonylamino-1-(5-aminocarbonyl-2-pyridyl)piperidine
반응식
[CH2:1]([N:3]([CH2:6][CH3:7])[CH2:4][CH3:5])[CH3:2].ClC1C=[CH:16][C:12]([C:13]([NH2:15])=[O:14])=[CH:11][N:10]=1.[OH2:18].C[N:20]([CH3:23])[CH:21]=[O:22]>>[C:12]([O:22][C:21]([NH:20][CH:23]1[CH2:5][CH2:4][N:3]([C:6]2[CH:7]=[CH:16][C:12]([C:13]([NH2:15])=[O:14])=[CH:11][N:10]=2)[CH2:1][CH2:2]1)=[O:18])([CH3:16])([CH3:13])[CH3:11]참가 물질
5
반응 조건
- 온도
- 80 °C
실험 절차
A mixture of 3 g (0.015 mol) of the product of preparation 1, 1.5 g (0.015 mol) of triethylamine and 2.34 g (0.015 mol) of 6-chloronicotinamide in 60 ml of dimethylformamide is heated at 80° C. for 18 hours. After cooling, water is added and the product is filtered off. 2.8 g of the title compound are thus obtained. m.p. 255° C. dec.