Water → 4-tert-Butoxycarbonylamino-1-(5-aminocarbonyl-2-pyridyl)piperidine

HRID 23564

반응식

HRID 23564 반응식
[CH2:1]([N:3]([CH2:6][CH3:7])[CH2:4][CH3:5])[CH3:2].ClC1C=[CH:16][C:12]([C:13]([NH2:15])=[O:14])=[CH:11][N:10]=1.[OH2:18].C[N:20]([CH3:23])[CH:21]=[O:22]>>[C:12]([O:22][C:21]([NH:20][CH:23]1[CH2:5][CH2:4][N:3]([C:6]2[CH:7]=[CH:16][C:12]([C:13]([NH2:15])=[O:14])=[CH:11][N:10]=2)[CH2:1][CH2:2]1)=[O:18])([CH3:16])([CH3:13])[CH3:11]

참가 물질

5

반응물 4

HCID 962WaterHCID 6228DimethylformamideHCID 8471TriethylamineHCID 804566-Chloronicotinamide

생성물 1

HCID 114840424-tert-Butoxycarbonylamino-1-(5-aminocarbonyl-2-pyridyl)piperidine

반응 조건

온도
80 °C

실험 절차

A mixture of 3 g (0.015 mol) of the product of preparation 1, 1.5 g (0.015 mol) of triethylamine and 2.34 g (0.015 mol) of 6-chloronicotinamide in 60 ml of dimethylformamide is heated at 80° C. for 18 hours. After cooling, water is added and the product is filtered off. 2.8 g of the title compound are thus obtained. m.p. 255° C. dec.

후처리

  1. temperatureAfter cooling
  2. filtrationthe product is filtered off

출처 및 근거

ORD 기록
ord-cea0b8f2a83640e79fadf2be389be974
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06852736B2

연결된 노트

불러오는 중…