Benzyl Bromide → (2-Benzyloxy-5-chloro-phenyl)-methanol

HRID 2356599노트

반응식

HRID 2356599 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([CH2:9][OH:10])[CH:3]=1.[CH2:11](Br)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[C:4]([CH2:9][OH:10])[CH:3]=1

참가 물질

5

반응물 3

HCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 792385-Chlorosalicyl alcohol

생성물 1

HCID 19317759(2-Benzyloxy-5-chloro-phenyl)-methanol수율 106.4%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

4-Chloro-2-(hydroxymethyl)phenol (5 g, 31 mmol), benzyl bromide (3.74 ml, 31 mmol), and potassium carbonate (4.78 g, 34 mmol) were refluxed in acetone (30 ml) for two hours. TLC showed no more SM (starting material). Cooled down, filtered off the solid and vacuumed down (the filtrate) to give a clear oil (8.2 g).

후처리

  1. temperatureCooled down
  2. filtrationfiltered off the solid

출처 및 근거

ORD 기록
ord-3b780a849f664864b3792684e5fa354a
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07759369B2

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