Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trimethyl borate → (5-Chloro-2-{[(4-chloro-2-fluorophenyl)methyl]oxy}phenyl)boronic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trimethyl borate | HCID 8470 | — |
| 반응물 | 4-Chloro-1-{[(4-chloro-2-fluorophenyl)methyl]oxy}-2-iodobenzene | HCID 24753687 | — |
| 반응물 | HCID 178418918 | HCID 178418918 | — |
| 생성물 | (5-Chloro-2-{[(4-chloro-2-fluorophenyl)methyl]oxy}phenyl)boronic acid | HCID 59384250 | — |
반응 단계
As for reaction 1, using 90.5 g 4-chloro-1-{[(4-chloro-2-fluorophenyl)methyl]oxy}-2-iodobenzene, 228 ml isopropylmagnesium chloride and 47.42 g trimethyl borate. Yield 66.8 g. NMR showed trace impurities. LCMS OK.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07759369B2 |
| 출처 데이터셋 | uspto-grants-2010_07 |
| ORD ID | ord-e3563bca37ad47acbaf70ac970b4d027 |
| 출처 메모 | uspto-grants-2010_07 |