Thionyl Chloride → 6-(Chloromethyl)-5-methyl-2-pyridinecarbonitrile
반응식
O[CH2:2][C:3]1[N:8]=[C:7]([C:9]#[N:10])[CH:6]=[CH:5][C:4]=1[CH3:11].S(Cl)([Cl:14])=O>ClCCl>[Cl:14][CH2:2][C:3]1[N:8]=[C:7]([C:9]#[N:10])[CH:6]=[CH:5][C:4]=1[CH3:11]참가 물질
4
실험 절차
A solution of 6-(hydroxymethyl)-5-methyl-2-pyridinecarbonitrile (184 mg) and thionyl chloride (0.16 ml) in dichloromethane (3.5 ml) was stirred at ambient temperature for 7 hours. Solvent was removed in vacuo and toluene (2 ml) added then removed in vacuo to afford the title compound (205 mg, 99%) as a pale buff solid.
후처리
- customSolvent was removed in vacuo and toluene (2 ml)
- additionadded
- customthen removed in vacuo
출처 및 근거
- ORD 기록
- ord-ab1a1929872747a595afb436cc78c92e
- 출처 데이터셋
- uspto-grants-2010_07
- 특허 번호
- US07759369B2
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