Chloroform methanol → Levcromakalim

HRID 235675

반응식

HRID 235675 반응식
[C:1]([C:3]1[CH:21]=[CH:20][C:6]2[O:7][C:8]([CH3:19])([CH3:18])[C@@H:9]([OH:17])[C@H:10]([N:11]3[CH2:15][CH2:14][CH2:13][CH:12]3[OH:16])[C:5]=2[CH:4]=1)#[N:2].I([O-])(=O)(=O)=O.[Na+].C(Cl)(Cl)Cl.CO.CCCCCCC.C(OCC)(=O)C.C(N(CC)CC)C>O.CO>[C:1]([C:3]1[CH:21]=[CH:20][C:6]2[O:7][C:8]([CH3:19])([CH3:18])[C@@H:9]([OH:17])[C@H:10]([N:11]3[CH2:15][CH2:14][CH2:13][C:12]3=[O:16])[C:5]=2[CH:4]=1)#[N:2]

참가 물질

6

반응물 4

HCID 21584188Chloroform methanolHCID 22311133HCID 22311133, 화합물HCID 23667635Sodium periodateHCID 67881644HCID 67881644, 화합물

생성물 1

HCID 93504Levcromakalim

시약·촉매·용매 1

HCID 22242641Methanol--water (1/1)용매

실험 절차

6-Cyano-3,4-dihyro-2,2-dimethyl-trans-4-(2-hydroxy-1-pyrrolidinyl)-2H-benzo[b]pyran-3-ol (5 mg), dissolved in methanol water (1 ml) was treated with an excess of sodium periodate with stirring during 15 hours at room temperature. Evaporation of solvents and extraction by ethyl acetate gave material having identical thin layer characteristics when applied to silica gel plates developed in either chloroform-methanol (15:1) or heptane-ethyl acetate-triethylamine and infra red spectrum to the title compound reported in Example 1 of U.S. Pat. No. 4,446,113.

후처리

  1. customEvaporation of solvents and extraction by ethyl acetate
  2. customgave material

출처 및 근거

ORD 기록
ord-13ee768044bc4073ace3e7dc76a2bd3e
출처 데이터셋
uspto-grants-1987_02
특허 번호
US04640928

연결된 노트

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