Ammonia → 3-Nitro-1-phenyl-1,2-dihydropyridin-2-one

HRID 2356862노트

반응식

HRID 2356862 반응식
[OH:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[C:11]1(B(O)O)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.C(N(CC)CC)C.N>C([O-])(=O)C.[Cu+2].C([O-])(=O)C.O1CCCC1.N1C=CC=CC=1>[N+:8]([C:7]1[C:2](=[O:1])[N:3]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:4]=[CH:5][CH:6]=1)([O-:10])=[O:9]

참가 물질

8

반응물 4

HCID 222AmmoniaHCID 8471TriethylamineHCID 66827Phenylboronic AcidHCID 178526677HCID 178526677, 화합물

생성물 1

HCID 223191573-Nitro-1-phenyl-1,2-dihydropyridin-2-one수율 61%

시약·촉매·용매 3

HCID 8895Cupric acetate촉매HCID 1049Pyridine용매HCID 8028Tetrahydrofuran용매

실험 절차

5 g of 2-hydroxy-3-nitropyridine, 7.14 g of phenylboronic acid, 2.6 g of copper (II) acetate, 9.9 ml of triethylamine and 5.8 ml of pyridine were added to 100 ml of tetrahydrofuran, followed by stirring overnight. The reaction mixture was poured into aqueous ammonia, and extracted with ethyl acetate. The organic layer was washed with water, dried, and concentrated. The residue was suspended into ether, and collected by filtration, to give 4.71 g of the title compound.

후처리

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed with water
  3. customdried
  4. concentrationconcentrated
  5. filtrationcollected by filtration

출처 및 근거

ORD 기록
ord-4b76c88344134945aad655eb52bc6d43
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07759367B2

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