Morpholine → N-[5-(4,4-Dimethyl-2,5-dioxo-3-pyridin-4-ylmethyl-imidazolidin-1-yl)-2-trifluoromethoxy-phenyl]-2-morpholin-4-yl-acetamide

HRID 2356934노트

반응식

HRID 2356934 반응식
[CH3:1][C:2]1([CH3:32])[C:6](=[O:7])[N:5]([C:8]2[CH:9]=[CH:10][C:11]([O:19][C:20]([F:23])([F:22])[F:21])=[C:12]([NH:14][C:15](=[O:18])[CH2:16]Cl)[CH:13]=2)[C:4](=[O:24])[N:3]1[CH2:25][C:26]1[CH:31]=[CH:30][N:29]=[CH:28][CH:27]=1.[NH:33]1[CH2:38][CH2:37][O:36][CH2:35][CH2:34]1>>[CH3:1][C:2]1([CH3:32])[C:6](=[O:7])[N:5]([C:8]2[CH:9]=[CH:10][C:11]([O:19][C:20]([F:23])([F:22])[F:21])=[C:12]([NH:14][C:15](=[O:18])[CH2:16][N:33]3[CH2:38][CH2:37][O:36][CH2:35][CH2:34]3)[CH:13]=2)[C:4](=[O:24])[N:3]1[CH2:25][C:26]1[CH:31]=[CH:30][N:29]=[CH:28][CH:27]=1

참가 물질

3

반응물 2

HCID 8083MorpholineHCID 23110283N-[5-(4,4-Dimethyl-2,5-dioxo-3-pyridin-4-ylmethyl-imidazolidin-1-yl)-2-trifluoromethoxy-phenyl]-2-chloro-acetamide

생성물 1

HCID 11642143N-[5-(4,4-Dimethyl-2,5-dioxo-3-pyridin-4-ylmethyl-imidazolidin-1-yl)-2-trifluoromethoxy-phenyl]-2-morpholin-4-yl-acetamide

실험 절차

50 mg N-[5-(4,4-Dimethyl-2,5-dioxo-3-pyridin-4-ylmethyl-imidazolidin-1-yl)-2-trifluoromethoxy-phenyl]-2-chloro-acetamide (raw material, as described above) owere dissolved in 2 ml morpholine and heated for 1 h to 50° C. Subsequently, the mixture was poured on ice and extracted with ethylacetate. The combined organic phases were evaporated to dryness and the residue was purified by flash chromoatography (Silica gel, methylene chloride:methanol=1.98:22.95:5) Yield: 20 mg

후처리

  1. temperatureheated for 1 h to 50° C
  2. additionSubsequently, the mixture was poured on ice
  3. extractionextracted with ethylacetate
  4. customThe combined organic phases were evaporated to dryness
  5. customthe residue was purified by flash chromoatography (Silica gel, methylene chloride:methanol=1.98:22.95:5) Yield: 20 mg

출처 및 근거

ORD 기록
ord-7c4e906c3c6e4cc689578e9045b16fa1
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07759379B2

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