Chlorotrimethylsilane → HCID 10345215, 화합물

HRID 2357476노트

반응식

HRID 2357476 반응식
[CH3:1][N:2]([CH3:33])[C:3]1([C:26]2[CH:31]=[CH:30][C:29]([F:32])=[CH:28][CH:27]=2)[CH2:8][CH2:7][CH:6]([CH2:9][C:10]([N:12]2[CH2:16][CH2:15][CH:14]([C:17]3[C:25]4[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=4)[NH:19][CH:18]=3)[CH2:13]2)=[O:11])[CH2:5][CH2:4]1.C[Si](C)(C)[Cl:36]>CC(CC)=O>[ClH:36].[CH3:33][N:2]([CH3:1])[C:3]1([C:26]2[CH:27]=[CH:28][C:29]([F:32])=[CH:30][CH:31]=2)[CH2:8][CH2:7][CH:6]([CH2:9][C:10]([N:12]2[CH2:16][CH2:15][CH:14]([C:17]3[C:25]4[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=4)[NH:19][CH:18]=3)[CH2:13]2)=[O:11])[CH2:5][CH2:4]1

참가 물질

4

반응물 2

HCID 6397ChlorotrimethylsilaneHCID 103452162-[4-dimethylamino-4-(4-fluorophenyl)cyclohexyl]-1-[3-(1H-indol-3-yl)pyrrolidine-1-yl]-ethanone

생성물 1

HCID 10345215HCID 10345215, 화합물수율 93%

시약·촉매·용매 1

HCID 6569Methyl Ethyl Ketone용매

실험 절차

The polar diastereoisomer of 2-[4-dimethylamino-4-(4-fluorophenyl)cyclohexyl]-1-[3-(1H-indol-3-yl)pyrrolidine-1-yl]-ethanone (329 mg, 0.73 mmole) was dissolved in ethyl methyl ketone (10 ml) and trimethylchlorosilane (0.14 ml, 1.1 mmole) was added, and the whole was stirred for 1.5 hours at RT. The precipitated hydrochloride was isolated in a yield of 93% (329 mg) and had an m.p. of 170°-177° C. (Example 41).

출처 및 근거

ORD 기록
ord-04675c1e51e341bfa472b72f82349792
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07759385B2

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