Dimethylamine → 5-bromo-4-methoxy-N,N-dimethylpyrimidin-2-amine

HRID 2357659노트

반응식

[CH3:1][NH:2][CH3:3].[Br:4][C:5]1[C:6]([O:12][CH3:13])=[N:7][C:8](Cl)=[N:9][CH:10]=1>>[Br:4][C:5]1[C:6]([O:12][CH3:13])=[N:7][C:8]([N:2]([CH3:3])[CH3:1])=[N:9][CH:10]=1

참가 물질

반응물 2

HCID 674Dimethylamine

HCID 36631435-Bromo-2-chloro-4-methoxypyrimidine

생성물 1

HCID 6158295-bromo-4-methoxy-N,N-dimethylpyrimidin-2-amine수율 98.2%

반응 조건

온도: 45 °C

실험 절차

A solution of dimethylamine (2.0 M solution in THF, 17.2 mL, 34.5 mmol) was added to 5-bromo-2-chloro-4-methoxypyrimidine (1.540 g, 6.89 mmol) at RT. The reaction was heated to 45° C. for 30 min, then cooled and concentrated. The residue was washed and filtered with diethyl ether to give 1.57 g of 5-bromo-4-methoxy-N,N-dimethylpyrimidin-2-amine as a light yellow solid. ES+=232.0 (M+H)

후처리

temperaturecooled
concentrationconcentrated
washThe residue was washed
filtrationfiltered with diethyl ether

출처 및 근거

ORD 기록: ord-14e03286722344c0b75b5b4c102047d8
출처 데이터셋: uspto-grants-2010_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07759337B2

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