Hydrazine → HCID 178518953, 화합물

반응식

Cl.[CH2:2]([N:9]1[CH2:14][CH2:13][CH:12]([C:15]([O:17]CC)=O)[C:11](=O)[CH2:10]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[NH2:21][NH2:22]>>[CH2:2]([N:9]1[CH2:14][CH2:13][C:12]2[C:15]([OH:17])=[N:21][NH:22][C:11]=2[CH2:10]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

참가 물질

반응물 2

HCID 9321Hydrazine

HCID 2723880Ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride

생성물 1

HCID 178518953HCID 178518953, 화합물

실험 절차

A mixture of ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride (10.0 g, 34 mmol, Aldrich) and hydrazine (30 mL, 824 mmol, Aldrich) was stirred at RT for 48 h. The volatile solvents were removed in vacuo, and the residue was azeotroped with MeOH (1×), then recrystallized from MeOH to obtain the title compound MS (ESI, pos. ion) m/z: 230 (M+1).

후처리

customThe volatile solvents were removed in vacuo
customthe residue was azeotroped with MeOH (1×)
customrecrystallized from MeOH

출처 및 근거

ORD 기록: ord-c9d3f1878d6c4095b468ce2d115b40fb
출처 데이터셋: uspto-grants-2010_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07759337B2

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