HCID 178518953, 화합물 → aza-THIP

HRID 2357681노트

반응식

HRID 2357681 반응식
C([N:8]1[CH2:13][CH2:12][C:11]2[C:14]([OH:17])=[N:15][NH:16][C:10]=2[CH2:9]1)C1C=CC=CC=1>[Pd].CO>[NH:16]1[C:10]2[CH2:9][NH:8][CH2:13][CH2:12][C:11]=2[C:14]([OH:17])=[N:15]1

참가 물질

4

반응물 1

HCID 178518953HCID 178518953, 화합물

생성물 1

HCID 178518952aza-THIP

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of 6-benzyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-3-ol (2.00 g, 8.72 mmol) and palladium on carbon (0.200 g, 1.88 mmol, Aldrich) in MeOH (100 mL) was stirred under H2 atmosphere for 48 h. The mixture was filtered through Celite® and the filter cake was washed with MeOH. The mixture was concentrated in vacuo. The filter cake was washed with water and the filtrate was concentrated in vacuo. Both fractions contained the title compound. MS (ESI, pos. ion) m/z: 140 (M+1).

후처리

  1. filtrationThe mixture was filtered through Celite®
  2. washthe filter cake was washed with MeOH
  3. concentrationThe mixture was concentrated in vacuo
  4. washThe filter cake was washed with water
  5. concentrationthe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-0a62205f17014cc2b18655f26601f55c
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07759337B2

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