Cyclobutanecarboxylic acid → N-(7-Chloro-1,8-naphthyridin-2-yl)cyclobutanecarboxamide

HRID 235804

반응식

HRID 235804 반응식
[CH:1]1([C:5]([OH:7])=O)[CH2:4][CH2:3][CH2:2]1.[NH2:8][C:9]1[CH:18]=[CH:17][C:16]2[C:11](=[N:12][C:13]([Cl:19])=[CH:14][CH:15]=2)[N:10]=1>C(#N)C>[Cl:19][C:13]1[N:12]=[C:11]2[C:16]([CH:17]=[CH:18][C:9]([NH:8][C:5]([CH:1]3[CH2:2][CH2:3][CH2:4]3)=[O:7])=[N:10]2)=[CH:15][CH:14]=1

참가 물질

4

반응물 2

HCID 19494Cyclobutanecarboxylic acidHCID 851997-Chloro-1,8-naphthyridin-2-amine

생성물 1

HCID 13579401N-(7-Chloro-1,8-naphthyridin-2-yl)cyclobutanecarboxamide수율 61.8%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

반응 조건

온도
20 °C

실험 절차

The procedure is similar to that described in Example 1, but starting with cyclobutanecarboxylic acid (5 g), N,N'-carbonyldiimidazole (10.5 g) and 2-amino-7chloro-1,8-naphthyridine (7 g). The product produced by filtration (9 g; m.p. 192° C.) is dissolved in boiling acetonitrile (150 cc). After 3 hours' cooling at 20° C., the crystallised solid is separated by filtration, washed with ethyl ether (3×25 cc) and dried at 35° C. under reduced pressure (0.066 kPa). N-(7-Chloro-1,8-naphthyridin-2-yl)cyclobutanecarboxamide (6.3 g) is produced, m.p. 192°-194° C. EXAMPLE 6

후처리

  1. customThe product produced by filtration (9 g; m.p. 192° C.)
  2. dissolutionis dissolved
  3. customthe crystallised solid is separated by filtration
  4. washwashed with ethyl ether (3×25 cc)
  5. customdried at 35° C. under reduced pressure (0.066 kPa)

출처 및 근거

ORD 기록
ord-f5e0ec581381469da34265eb7464f9fc
출처 데이터셋
uspto-grants-1987_02
특허 번호
US04642308

연결된 노트

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