Cyclobutanecarboxylic acid → N-(7-Chloro-1,8-naphthyridin-2-yl)cyclobutanecarboxamide
반응식
[CH:1]1([C:5]([OH:7])=O)[CH2:4][CH2:3][CH2:2]1.[NH2:8][C:9]1[CH:18]=[CH:17][C:16]2[C:11](=[N:12][C:13]([Cl:19])=[CH:14][CH:15]=2)[N:10]=1>C(#N)C>[Cl:19][C:13]1[N:12]=[C:11]2[C:16]([CH:17]=[CH:18][C:9]([NH:8][C:5]([CH:1]3[CH2:2][CH2:3][CH2:4]3)=[O:7])=[N:10]2)=[CH:15][CH:14]=1참가 물질
4
반응 조건
- 온도
- 20 °C
실험 절차
The procedure is similar to that described in Example 1, but starting with cyclobutanecarboxylic acid (5 g), N,N'-carbonyldiimidazole (10.5 g) and 2-amino-7chloro-1,8-naphthyridine (7 g). The product produced by filtration (9 g; m.p. 192° C.) is dissolved in boiling acetonitrile (150 cc). After 3 hours' cooling at 20° C., the crystallised solid is separated by filtration, washed with ethyl ether (3×25 cc) and dried at 35° C. under reduced pressure (0.066 kPa). N-(7-Chloro-1,8-naphthyridin-2-yl)cyclobutanecarboxamide (6.3 g) is produced, m.p. 192°-194° C. EXAMPLE 6