Methyl chloroformate → Methyl 4-[2-fluoro-3-(methylthio)phenyl]piperazine-1-carboxylate

HRID 2358139

반응식

HRID 2358139 반응식
[F:1][C:2]1[C:7]([S:8][CH3:9])=[CH:6][CH:5]=[CH:4][C:3]=1[N:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1.C(N(CC)CC)C.Cl[C:24]([O:26][CH3:27])=[O:25]>C(Cl)Cl>[F:1][C:2]1[C:7]([S:8][CH3:9])=[CH:6][CH:5]=[CH:4][C:3]=1[N:10]1[CH2:15][CH2:14][N:13]([C:24]([O:26][CH3:27])=[O:25])[CH2:12][CH2:11]1

참가 물질

5

반응물 3

HCID 6586Methyl chloroformateHCID 8471TriethylamineHCID 574480731-[2-Fluoro-3-(methylthio)phenyl]piperazine

생성물 1

HCID 57448074Methyl 4-[2-fluoro-3-(methylthio)phenyl]piperazine-1-carboxylate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Preparation according to preparation 26: 1-[2-fluoro-3-(methylthio)phenyl]piperazine (1.25 g, 5.53 mmol), triethylamine (1.2 ml, 7.2 mmol), methylen chloride (50 ml), methyl chloroformate (0.49 g, 6.6 mmol). Yield: 1.56 g. MS m/z (rel. intensity, 70 eV) 284 (M+, 99), 196 (bp), 184 (44), 169 (54), 56 (60).

후처리

  1. customPreparation
  2. customaccording to preparation 26

출처 및 근거

ORD 기록
ord-867b123a2aa4466b9311c7d11765273e
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07763639B2

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