4-Bromo-7a-methyl-hexahydro-indene-1,5-dione → 4-Allyloxy-7a-methyl-hexahydro-indene-1,5-dione

HRID 2358270노트

반응식

HRID 2358270 반응식
Br[CH:2]1[C:10](=[O:11])[CH2:9][CH2:8][C:7]2([CH3:12])[CH:3]1[CH2:4][CH2:5][C:6]2=[O:13]>C(O)C=C>[CH2:10]([O:11][CH:2]1[C:10](=[O:11])[CH2:9][CH2:8][C:7]2([CH3:12])[CH:3]1[CH2:4][CH2:5][C:6]2=[O:13])[CH:9]=[CH2:8]

참가 물질

3

반응물 1

HCID 141132994-Bromo-7a-methyl-hexahydro-indene-1,5-dione

생성물 1

HCID 684575234-Allyloxy-7a-methyl-hexahydro-indene-1,5-dione

시약·촉매·용매 1

HCID 7858Allyl Alcohol용매

실험 절차

To the stirred suspension of 4-bromo-7a-methyl-hexahydro-indene-1,5-dione 1 (prepared according to the procedure described in J. Org. Chem. 2001, 66, 626.) (2.44 g, 10 mmol), molecular sieves of 4 Å (2.5 g) and silica gel (2.5 g) in allyl alcohol (20 mL) was added Ag2O (2.55 g, 11 mmol) at room temperature. The reaction mixture was stirred at room temperature in the dark for 8 h. The reaction mixture was filtered through a mixture of Celite® and silica gel. The solvent was removed under reduced pressure to yield the title compound as a crude yellow oil.

후처리

  1. customprepared
  2. filtrationThe reaction mixture was filtered through a mixture of Celite® and silica gel
  3. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-86f823d3f7ed40d1b438dae46a6f298b
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07763648B2

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