Toluene → N-[4-(1-Aminoethyl)-2-fluoro-6-vinylphenyl]methanesulfonamide
반응식
C(OC(=O)[NH:7][CH:8]([C:10]1[CH:15]=[C:14]([CH:16]=[CH2:17])[C:13]([NH:18][S:19]([CH3:22])(=[O:21])=[O:20])=[C:12]([F:23])[CH:11]=1)[CH3:9])(C)(C)C.C1(C)C=CC=CC=1>C(Cl)Cl.C(O)(C(F)(F)F)=O>[NH2:7][CH:8]([C:10]1[CH:15]=[C:14]([CH:16]=[CH2:17])[C:13]([NH:18][S:19]([CH3:22])(=[O:21])=[O:20])=[C:12]([F:23])[CH:11]=1)[CH3:9]참가 물질
5
실험 절차
[1-(3-fluoro-4-methanesulfonylamino-5-vinyl phenyl)ethyl]carbamic acid tert-butyl ester (0.06 mmol, 20.2 mg) was dissolved in methylene chloride, 5˜6 drops of CF3COOH were added. A reaction mixture was stirred for 12 hr. A toluene was added. The reaction mixture was concentrated in vacuo to yield brownish syrup (20.8 mg, 100.0%).
후처리
- concentrationThe reaction mixture was concentrated in vacuo
출처 및 근거
- ORD 기록
- ord-cb073f7511d04f34b05d8bfb1cf903e4
- 출처 데이터셋
- uspto-grants-2010_07
- 특허 번호
- US07763657B2
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