Triethylamine → (3-Chloro-4-methanesulfonylamino-5-vinylbenzyl)carbamic Acid tert-butyl Ester

HRID 2358382노트

반응식

HRID 2358382 반응식
[C:1]([O:5][C:6](=[O:19])[NH:7][CH2:8][C:9]1[CH:14]=[C:13]([CH:15]=[CH2:16])[C:12]([NH2:17])=[C:11]([Cl:18])[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:20][S:21](Cl)(=[O:23])=[O:22].C(N(CC)CC)C>C(Cl)Cl>[C:1]([O:5][C:6](=[O:19])[NH:7][CH2:8][C:9]1[CH:14]=[C:13]([CH:15]=[CH2:16])[C:12]([NH:17][S:21]([CH3:20])(=[O:23])=[O:22])=[C:11]([Cl:18])[CH:10]=1)([CH3:4])([CH3:2])[CH3:3]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 68456355(4-Amino-3-chloro-5-vinylbenzyl)carbamic acid tert-butyl ester

생성물 1

HCID 68456846(3-Chloro-4-methanesulfonylamino-5-vinylbenzyl)carbamic Acid tert-butyl Ester수율 60.8%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

(4-Amino-3-chloro-5-vinylbenzyl)carbamic acid tert-butyl ester (40.2 mg, 0.14 mmol), methanesulfonyl chloride (5 eq, 0.71 mmol, 55.15 μl), and triethylamine (3 eq, 0.42 mmol, 58.34 μl) were added in methylene chloride. The reaction mixture was stirred for 5 hr. The reaction mixture was purified with similar procedure to step 5 of Example 8 to obtain a title compound (30.7 mg, 59.83%).

후처리

  1. customThe reaction mixture was purified with similar procedure to step 5 of Example 8

출처 및 근거

ORD 기록
ord-23a8ff67468749bcbc721f217bf51e11
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07763657B2

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