(3-Chloro-4-methanesulfonylamino-5-vinylbenzyl)carbamic Acid tert-butyl Ester → N-(4-Aminomethyl-2-chloro-6-vinylphenyl)methanesulfonamide

HRID 2358383노트

반응식

HRID 2358383 반응식
C(OC(=O)[NH:7][CH2:8][C:9]1[CH:14]=[C:13]([CH:15]=[CH2:16])[C:12]([NH:17][S:18]([CH3:21])(=[O:20])=[O:19])=[C:11]([Cl:22])[CH:10]=1)(C)(C)C>C(O)(C(F)(F)F)=O.C(Cl)Cl>[NH2:7][CH2:8][C:9]1[CH:14]=[C:13]([CH:15]=[CH2:16])[C:12]([NH:17][S:18]([CH3:21])(=[O:20])=[O:19])=[C:11]([Cl:22])[CH:10]=1

참가 물질

4

반응물 1

HCID 68456846(3-Chloro-4-methanesulfonylamino-5-vinylbenzyl)carbamic Acid tert-butyl Ester

생성물 1

HCID 68457636N-(4-Aminomethyl-2-chloro-6-vinylphenyl)methanesulfonamide수율 142.3%

시약·촉매·용매 2

HCID 6422Trifluoroacetic acid촉매HCID 6344Dichloromethane용매

실험 절차

(3-Chloro-4-methanesulfonylamino-5-vinylbenzyl)carbamic acid tert-butyl ester (30.7 mg, 0.09 mmol) and CF3COOH (5-6 drops) was added into methylene chloride. The reaction mixture was stirred for 12 hr. The reaction mixture was concentrated in vacuo to give a title compound (33.4 mg, 100%).

후처리

  1. concentrationThe reaction mixture was concentrated in vacuo

출처 및 근거

ORD 기록
ord-05d2eca1ddd847f5a9a7796deca4f718
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07763657B2

반응 노트

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