Methanol → 6-Methoxynicotinic acid

HRID 235850

반응식

HRID 235850 반응식
Cl[C:2]1[N:7]=[CH:6][C:5]([C:8]([OH:10])=[O:9])=[CH:4][CH:3]=1.[CH3:11][OH:12]>C[O-].[Na+]>[CH3:11][O:12][C:2]1[N:7]=[CH:6][C:5]([C:8]([OH:10])=[O:9])=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 887MethanolHCID 792226-Chloronicotinic acid

생성물 1

HCID 5924996-Methoxynicotinic acid

시약·촉매·용매 1

HCID 10942334Sodium Methoxide용매

실험 절차

To a suspension of 6-chloropyridine-3-carboxylic acid (4.15 g) in methanol (40 cc), 4 M methanolic sodium methylate solution (40 cc) is added. The mixture is heated under reflux for 60 hours. The solvent is distilled off under reduced pressure (4 kPa). The residue is taken up in distilled water (100 cc) and the mixture is acidified to pH 5 with hydrochloric acid in 11.9 M aqueous solution. The precipitate produced is separated by filtration, washed with distilled water (5×10 cc) and dried in the air. 6-Methoxypyridine-3-carboxylic acid (3.3 g) is produced, m.p. 180° C.

후처리

  1. additionis added
  2. temperatureThe mixture is heated
  3. temperatureunder reflux for 60 hours
  4. distillationThe solvent is distilled off under reduced pressure (4 kPa)
  5. customThe precipitate produced
  6. customis separated by filtration
  7. washwashed with distilled water (5×10 cc)
  8. customdried in the air

출처 및 근거

ORD 기록
ord-25f2f5f4775e4709968269a240fc8baa
출처 데이터셋
uspto-grants-1987_02
특허 번호
US04642308

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