참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Acetonitrile | HCID 6342 | — |
| 반응물 | 6-Methoxynicotinic acid | HCID 592499 | — |
| 반응물 | 2-Amino-7-phenoxy-1,8-naphthyridine | HCID 13787373 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | HCID 20217521 | HCID 20217521 | 61.2% |
반응 단계
The procedure is similar to that described in Example 1, but starting with 6-methoxypyridine-3-carboxylic acid (4.7 g), N,N'-carbonyldiimidazole (4.9 g) and 2-amino-7-phenoxy-1,8-naphthyridine (9.1 g). The product produced by precipitation in water (11 g; m.p. 115° C.) is dissolved in boiling acetonitrile (50 cc). After 10 hours' cooling at 20° C., the crystallised solid is separated by filtration, washed with diisopropyl ether (3×10 cc) and dried at 30° C. under reduced pressure (0.067 kPa). N-(7-Phenoxy-1,8-naphthyridin-2-yl)-6-methoxypyridine-3-carboxamide (7 g) is produced, m.p. 115°-120° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04642308 |
|---|
| 출처 데이터셋 | uspto-grants-1987_02 |
|---|
| ORD ID | ord-221d2b16da6d4fa2a8a2febea3b47d16 |
|---|
| 출처 메모 | uspto-grants-1987_02 |
|---|
