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Ethanol → N-(7-Phenoxy-1,8-naphthyridin-2-yl)-2-furancarboxamide

HRID 235859
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HRID 235859 반응식
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([OH:8])=O.[NH2:9][C:10]1[CH:19]=[CH:18][C:17]2[C:12](=[N:13][C:14]([O:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)=[CH:15][CH:16]=2)[N:11]=1.C(O)C>O>[O:20]([C:14]1[N:13]=[C:12]2[C:17]([CH:18]=[CH:19][C:10]([NH:9][C:6]([C:2]3[O:1][CH:5]=[CH:4][CH:3]=3)=[O:8])=[N:11]2)=[CH:16][CH:15]=1)[C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 702EthanolHCID 69192-Furancarboxylic acidHCID 137873732-Amino-7-phenoxy-1,8-naphthyridine

생성물 1

HCID 20217509N-(7-Phenoxy-1,8-naphthyridin-2-yl)-2-furancarboxamide수율 86.7%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
4 °C

실험 절차

The procedure is similar to that described in Example 1, but starting with 2-furancarboxylic acid (7.5 g), N,N'-carbonyldiimidazole (10.9 g) and 2-amino-7-phenoxy-1,8-naphthyridine (11.9 g). The product produced by precipitation in water (15.7 g; m.p. 164° C.) is dissolved in boiling ethanol (200 cc). After 2 hours' cooling at 4° C., the crystallised solid is separated by filtration, washed with ethanol (15 cc) and dried at 40° C. under reduced pressure (0.067 kPa). N-(7-Phenoxy-1,8-naphthyridin-2-yl)-2-furancarboxamide (14.4 g) is produced, m.p. 167° C.

후처리

  1. dissolutionis dissolved
  2. customthe crystallised solid is separated by filtration
  3. washwashed with ethanol (15 cc)
  4. customdried at 40° C. under reduced pressure (0.067 kPa)

출처 및 근거

ORD 기록
ord-5e9f7f2c77d5410e97f5ab8929bd8415
출처 데이터셋
uspto-grants-1987_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04642308

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