N-Methylethylamine → 4-(4-chloro-2-nitrophenoxy)-N-ethyl-N-methylbenzamide

HRID 2358698노트

반응식

HRID 2358698 반응식
[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][C:7]2[CH:15]=[CH:14][C:10]([C:11](Cl)=[O:12])=[CH:9][CH:8]=2)=[C:4]([N+:18]([O-:20])=[O:19])[CH:3]=1.[CH3:21][NH:22][CH2:23][CH3:24]>C(Cl)Cl>[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][C:7]2[CH:15]=[CH:14][C:10]([C:11]([N:22]([CH2:23][CH3:24])[CH3:21])=[O:12])=[CH:9][CH:8]=2)=[C:4]([N+:18]([O-:20])=[O:19])[CH:3]=1

참가 물질

4

반응물 2

HCID 12219N-MethylethylamineHCID 866154944-(4-Chloro-2-nitrophenoxy)benzoyl chloride

생성물 1

HCID 684597124-(4-chloro-2-nitrophenoxy)-N-ethyl-N-methylbenzamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

The compound from Example 126c (1.0 g, 3.2 mmol) in CH2Cl2 was added to a mixture of N-methylethanamine (379 mg, 6.41 mmol) in CH2Cl2. Mixture was stirred for 12 hours. Mixture was concentrated under vacuum giving the title compound, which was purified by silica gel column chromatography eluting with 50% EtOAc/hexane giving a yellow oil (1.03 g, 100%).

후처리

  1. concentrationMixture was concentrated under vacuum

출처 및 근거

ORD 기록
ord-b5950ceb20154c2c966813f1148fbd05
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07763731B2

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