2-Nitro-biphenyl-4-carboxylic acid methyl ester → Methyl 2-amino-[1,1'-biphenyl]-4-carboxylate

HRID 2358805

반응식

HRID 2358805 반응식
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[C:7]([N+:17]([O-])=O)[CH:6]=1)=[O:4]>C(O)C>[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)=[C:7]([NH2:17])[CH:6]=1)=[O:4]

참가 물질

3

반응물 1

HCID 121698042-Nitro-biphenyl-4-carboxylic acid methyl ester

생성물 1

HCID 67497797Methyl 2-amino-[1,1'-biphenyl]-4-carboxylate

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

The product from Example 212b (0.0795 g, 0.309 mmol) was dissolved in ethanol (2 mL) and to this solution was added Pt(IV) oxide (5.2 mg). The reaction mixture was vacuum degassed then exposed to one atmosphere of hydrogen for 3 h at room temperature. The catalyst was removed by filtration through celite and the filtrate concentrated under vacuum to give the title compound in quantitative yield.

후처리

  1. customdegassed
  2. customThe catalyst was removed by filtration through celite
  3. concentrationthe filtrate concentrated under vacuum

출처 및 근거

ORD 기록
ord-f53744894b0144d3985e50101d84997a
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07763731B2

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