Potassium Hydroxide → 5-(Furan-3-yl)-1,3-oxazole-4-carboxylic acid
반응식
[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[O:10][CH:9]=[N:8][C:7]=2[C:11]([O:13]C)=[O:12])=[CH:2]1.[OH-].[K+]>CO>[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[O:10][CH:9]=[N:8][C:7]=2[C:11]([OH:13])=[O:12])=[CH:2]1참가 물질
4
실험 절차
3 g of methyl 5-(3-furyl)oxazole-4-carboxylate and 2.6 g of 85% potassium hydroxide are dissolved in 100 ml of methanol, and the solution is stirred at room temperature overnight. Then, the reaction mixture is evaporated under reduced pressure to remove solvent, and the residue is acidified with dil. hydrochloric acid. The precipitated crystals are collected by filtration, washed with cold water and then dried. 2.6 g of 5-(3-furyl)oxazole-4-carboxylic acid are thereby obtained. Yield: 93.7%
후처리
- customThen, the reaction mixture is evaporated under reduced pressure
- customto remove solvent
- filtrationThe precipitated crystals are collected by filtration
- washwashed with cold water
- customdried
출처 및 근거
- ORD 기록
- ord-47f38b7fbd97494f9e212cac11356d8f
- 출처 데이터셋
- uspto-grants-1987_02
- 특허 번호
- US04642313
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